In individuals afflicted with hemophilia, characterized by a deficiency of coagulation FRESH PLUS factor VIII (FVIII), the occurrence of spontaneous recurrent intra-articular hemorrhage precipitates the emergence of hemophilic arthropathy (HA).Although clotting factor replacement therapy reduces joint bleeding clinically, clotting factors need to b
Objectives/Goals: Immune checkpoint inhibitors (IO) have dramatically improved survival outcomes in patients with metastatic melanoma.Still, many patients do not respond these treatments, and others may experience harmful adverse events (irAEs).Thus, there an unmet need for biomarkers for real-time monitoring and management of patients exposed to I
cardigans Abstract Background Metastatic breast cancer (BCa) is most often diagnosed months after completion of treatment of the primary tumor when a patient reports physical symptoms.Besides a physical examination, no other alternative recurrence screening method is recommended for routine follow-up care.Detection of autoantibodies against tumor-a
Elevated extracellular potassium chloride is widely used to achieve membrane depolarization of cultured neurons.This technique has illuminated mechanisms of calcium influx through L-type voltage sensitive calcium channels, activity-regulated signaling, downstream transcriptional events, and many other intracellular responses to depolarization.Howev